Tocolytics are agents which decrease uterine tone. Tocolytics include:
All tocolytics are discussed in more detail elsewhere - this covers just the mechanism of action of their uterine effects.
|Drug||β2-agonists||Ca2+-channel antagonists||COX Inhibitors|
|Mechanism of Action||Activate GPCR, ↑ cAMP, which activiates protein kinase A and leads to inhibition of myosin light chain kinase and relaxation||Block L-type Ca2+ channels, causing relaxation||Inhibit prostaglandin synthesis, which are vital for uterine contraction|