Direct Thrombin Inhibitors
Direct thrombin inhibitors prevent cleavage of fibrinogen to fibrin, and are therefore very effective anticoagulants.
|Uses||VTE prophylaxis, AF|
|Route of Administration||PO|
|Dosing||VTE: 220mg daily, AF: 150mg BD|
|Distribution||35% protein bound|
|Metabolism||Prodrug - activated by plasma and hepatic esterases|
|Elimination||Renal elimination of active drug|
|Other||Significant interactions with amiodarone, quinidine, St. John's Wort, as well as other anticoagulant and antiplatelet agents. Dialysable. Potentially reversible with idarucizumab.|
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