Angiotensin Receptor Blockers
Angiotensin receptor antagonists are very similar to ACE inhibitors, except:
- Bradykinin does not accumulate as it is still broken down by ACE
Therefore there is no cough and patient compliance is improved.
- The AT1 receptor in cardiac tissue is more comprehensively blocked which may improve cardiac outcomes
- The AT2 receptor is not blocked, which may also improve cardiac outcomes
- Peck TE, Hill SA. Pharmacology for Anaesthesia and Intensive Care. 4th Ed. Cambridge University Press. 2014.